Tertiary lymphoid structure-related score as a predictor for survival prognosis and immunotherapy response in head and neck squamous cell carcinoma
Our study presents a predictive model for TLS, which can evaluate its presence and predicts survival prognosis and immunotherapy response in HNSSC patients. Additionally, we identify a specific subtype of T cells that might elucidate the mechanism of TLS function in anti-tumor activities. This T cell subtype holds the potential to be a prognostic marker and a target for adoptive cell therapy (ACT) in the future.
Authors
- Jintao Li (ORCID: https://orcid.org/0000-0003-3637-2386)
- Qunxing Li
- Xin Liu (ORCID: https://orcid.org/0000-0002-6542-3181)
- Binbin Xia (ORCID: https://orcid.org/0009-0005-2712-6871)
- Shijia Kuang
- Ruixin Wang (ORCID: https://orcid.org/0000-0002-4395-8492)
- Suling Chen
- Yanyan Li (ORCID: https://orcid.org/0009-0005-7231-9293)
- Bowen Li (ORCID: https://orcid.org/0000-0003-0148-5030)
- Jiali Chen (ORCID: https://orcid.org/0000-0001-7929-5136)
- Fan Wu (ORCID: https://orcid.org/0000-0002-4135-2227)
- Haotian Cao
- Tianjun Lan (ORCID: https://orcid.org/0000-0002-5680-6164)
- Jiaying Wu (ORCID: https://orcid.org/0009-0001-3843-7115)
- Siqi Ren (ORCID: https://orcid.org/0000-0002-1734-6230)
- Qiuping Xu (ORCID: https://orcid.org/0000-0002-4163-6676)
- Liansheng Wang (ORCID: https://orcid.org/0000-0001-8538-6560)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- The First People's Hospital of Shunde (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1483497
- Citations
- 5
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.90