Associations of ethnicity, skin tone, and genome-wide sequencing with bone mineral density in adolescents
Current bone density reference databases include a binary assignment of patients into "Black" and "non-Black" categories, as a higher BMD has been documented among those identifying as Black compared with individuals of other racial and ethnic backgrounds. This study found genetic similarity to be more strongly associated with bone density by dual-energy x-ray absorptiometry than race or skin tone. These data emphasize a need to reevaluate how bone density measurements are interpreted, including exploring reference data that exclude the consideration of race.
Authors
- Emily Oken
- Abby F. Fleisch (ORCID: https://orcid.org/0000-0002-2789-6412)
- Lisa B. Rokoff
- Catherine M. Gordon (ORCID: https://orcid.org/0000-0001-8988-7186)
- Marie‐France Hivert (ORCID: https://orcid.org/0000-0001-7752-2585)
- Jean L. Raphael (ORCID: https://orcid.org/0000-0002-8612-1705)
- Sheryl L. Rifas‐Shiman
Institutions
- Maine Medical Center (US)
- Harvard University (US)
- Baylor College of Medicine (US)
- Massachusetts General Hospital (US)
- MaineHealth (US)
- Harvard Pilgrim Health Care (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1038/s41390-024-03588-4
- Citations
- 6
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.30
Funders
- National Institutes of Health