Two-stage group-sequential designs with delayed responses – what is the point of applying corresponding methods?
This research extends existing literature on group-sequential designs by offering insights into differences in performance. We conclude that, given the overall marginal differences, discussions regarding appropriate trial designs can pivot towards practical considerations of operational feasibility.
Authors
- Gernot Wassmer (ORCID: https://orcid.org/0000-0001-9397-1794)
- Carolin Herrmann (ORCID: https://orcid.org/0000-0003-2384-7303)
- Stephen Schüürhuis
- Cornelia Ursula Kunz (ORCID: https://orcid.org/0000-0002-8900-9401)
- Friedrich Pahlke (ORCID: https://orcid.org/0000-0003-2105-2582)
- Meinhard Kieser (ORCID: https://orcid.org/0000-0003-2402-4333)
Institutions
- Boehringer Ingelheim (Germany) (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Humboldt-Universität zu Berlin (DE)
- Zimmer Biomet (Germany) (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Heinrich Heine University Düsseldorf (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s12874-024-02363-7
- Primary Topic
- Optimal Experimental Design Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Charité – Universitätsmedizin Berlin