Advancing the Internet of Bio-Nano Things: A Novel DNA-Based Track-Hopper System for Enhanced Efficiency and Reliability

The thriving domain of the Internet of Bio-Nano Things (IoBNT) promises revolutionary advances in biomedicine, enabling biosensing, health monitoring, and therapeutic capabilities at the cellular level. A pivotal challenge, however, lies in devising reliable, efficient communication mechanisms within this bio-nano realm. This article introduces an emerging DNA-based molecular communication (MC) system utilizing a novel track-hopper mechanism that significantly enhances precision and control in molecular cargo transport. By leveraging DNA strands for information encoding and cargo transport, our track-hopper-based MCs (THMCs) IoBNT system achieves a symbiosis of high reliability, low delay, and precise directional control, surpassing traditional diffusion and motor-based methods. Through extensive theoretical analysis and simulation of network topology’s link and node response functions, we demonstrate the system’s superior performance in network delay and reliability metrics, underpinning its potential to redefine communication within IoBNT for applications ranging from health monitoring to disease detection. Our findings illuminate a path forward in bio-nano information exchange, offering a robust framework for the next generation of IoBNT systems.