Endothelial cells derived extracellular vesicles promote diabetic arterial calcification via circ_0008362/miR-1251-5p/Runx2 axial
Our findings suggested that circ_0008362 was enriched in EVs derived from ECs and promoted VSMC calcification under HG conditions, both by sponging miR-1251-5p to upregulate Runx2 expression and through direct interaction with Runx2. Furthermore, elevated levels of plasma EVs circ_0008362 were associated with more severe coronary and aorta artery calcification in patients with DM. These results may serve as a potential prevention and therapeutic target for diabetic arterial calcification.
Authors
- Su‐Kang Shan (ORCID: https://orcid.org/0000-0003-2907-2190)
- Yun-Yun Wu
- Xiao‐Bo Liao (ORCID: https://orcid.org/0000-0002-6413-4257)
- Fu‐Xing‐Zi Li
- Jia-Yue Duan
- Ke-Xin Tang
- Rongrong Cui (ORCID: https://orcid.org/0000-0002-6799-894X)
- Li-Min Lei
- Xiao Lin (ORCID: https://orcid.org/0000-0002-6039-3630)
- Junjie Yang (ORCID: https://orcid.org/0000-0001-8032-1418)
- Yanlin Wu (ORCID: https://orcid.org/0000-0003-4015-8972)
- Bei Huang (ORCID: https://orcid.org/0000-0001-8029-0367)
- Ming-Hui Zheng (ORCID: https://orcid.org/0000-0002-9854-3454)
- Ling‐Qing Yuan (ORCID: https://orcid.org/0000-0001-8602-7113)
- Feng Xu
- Feng Wu
- Sen He
- Jun Liu (ORCID: https://orcid.org/0000-0003-1179-7126)
Institutions
- Central South University (CN)
- Xinjiang Medical University (CN)
- Changsha Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s12933-024-02440-7
- Citations
- 17
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- Key Project of Research and Development Plan of Hunan Province
- National Natural Science Foundation of China
- Central South University
- Xiangya Hospital, Central South University
- Fundamental Research Funds for the Central Universities
- Fundamental Research Funds for Central Universities of the Central South University