Gram-Scale Synthesis of the Fucose-Containing Fragments of Saccharomicins
A highly efficient synthetic route has been established for the gram-scale production of fucose-aglycon (Fuc-Agl) and fucose-saccharosamine (Fuc-Sac) fragments in saccharomicins A and B. The β-glycosidic bonds within these structural components were formed through successive rhodium(II) and Brønsted-acid-catalyzed glycosylation, utilizing a stable thioglycosyl donor. Subsequent steps involving the installation of protecting groups yielded highly functionalized synthetic fragments that are suitable for further assembly of saccharomicins.
Authors
- Jing Zeng (ORCID: https://orcid.org/0000-0001-9116-9861)
- Qian Wan (ORCID: https://orcid.org/0000-0001-9243-8939)
- Shiwei Xu (ORCID: https://orcid.org/0000-0003-4739-8186)
- Dengxian Fu
- Ting Li (ORCID: https://orcid.org/0000-0001-5632-4475)
- Lingkui Meng (ORCID: https://orcid.org/0000-0001-7224-677X)
Institutions
- Wuhan University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1021/acs.orglett.4c03599
- Citations
- 2
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China