Electrochemical Umpolung α-Alkoxylation of Thiophene-Containing Amides
Traditional methods of the α-oxidation of amides often require preactivation or umpolung of amides. In this study, we introduce a general electrochemical approach for the direct α-C(<i>sp</i><sup>3</sup>)-H alkoxylation of thiophene-containing amides. This mild and selective electrochemical method provides a modular and alternative efficient route to the highly valuable α-oxygenated thiophene-containing amide scaffolds.
Authors
- Yunge Liu (ORCID: https://orcid.org/0000-0001-5955-3660)
- Han‐Xiang Deng (ORCID: https://orcid.org/0000-0002-0030-8465)
- Yunfei Zhang (ORCID: https://orcid.org/0000-0002-3018-6825)
Institutions
- China Agricultural University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1021/acs.joc.4c01632
- Citations
- 5
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China