HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis
Collectively, these data indicate that HPV16 integration hot spot c-Myc plays a novel and indispensable role in ferroptosis resistance by regulating the miR-142-5p/HOXA5/SLC7A11 signalling axis and suggest a potential therapeutic approach for HPV16 integration-related CSCC.
Authors
- Liangsheng Fan (ORCID: https://orcid.org/0000-0003-0043-3108)
- Zi‐Ci Wang
- Chu-Hong Guo
- Wei Wang (ORCID: https://orcid.org/0000-0002-3422-0402)
- Yang� Yang (ORCID: https://orcid.org/0000-0003-1222-1209)
- Xiaojing Chen
- Xiaofeng Cui (ORCID: https://orcid.org/0009-0002-5423-7786)
- Yan Cai (ORCID: https://orcid.org/0000-0003-1014-1547)
- Yunyi Liang
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s13578-024-01309-2
- Citations
- 12
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province