Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab
A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.
Authors
- Kenji Tsuchihashi (ORCID: https://orcid.org/0000-0002-9014-6382)
- Takashi Matsumura (ORCID: https://orcid.org/0000-0002-5817-8819)
- Fumiaki Jinnouchi (ORCID: https://orcid.org/0000-0003-1031-1980)
- Yoshinao Oda (ORCID: https://orcid.org/0000-0001-9636-1182)
- Hiroshi Ariyama (ORCID: https://orcid.org/0000-0002-8374-5045)
- Wataru Kusano
- Mamoru Ito (ORCID: https://orcid.org/0000-0002-9300-825X)
- Hirofumi Ohmura (ORCID: https://orcid.org/0000-0003-4650-9120)
- Kohei Arimizu
- Eishi Baba (ORCID: https://orcid.org/0000-0001-9428-6772)
- Taichi Isobe (ORCID: https://orcid.org/0000-0001-5686-1940)
- Yuki Kuma (ORCID: https://orcid.org/0000-0002-5131-5585)
- Akashi Koichi
- Shohei Moriyama (ORCID: https://orcid.org/0000-0002-0503-175X)
- Toshihiro Yamaguchi (ORCID: https://orcid.org/0000-0002-5458-5345)
- Takeo Yamamoto
- Yukio KUSUMOTO
Institutions
- Kyushu University (JP)
- Kyushu University Hospital (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2024-10-17
- DOI
- https://doi.org/10.2169/internalmedicine.3743-24
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85