Enantioselective Synthesis of Axially Chiral Silacyclohexylidene Oxime Ethers by Chiral Phosphoric Acid Catalysis
Abstract The first asymmetric condensation of prochiral silacyclohexanones with hydroxylamines by chiral phosphoric acid catalysis has been developed, which provides a facile and straightforward protocol for the enantioselective construction of valuable axially chiral silacyclohexylidene oxime ethers that are otherwise inaccessible. Notably, this constitutes a rare example for accessing silacycles featuring axial chirality.
Authors
- Xingang Xie (ORCID: https://orcid.org/0000-0002-0707-1229)
- Jin‐Sheng Yu (ORCID: https://orcid.org/0000-0002-0619-2037)
- Guang‐Ying Chen (ORCID: https://orcid.org/0000-0002-6729-0597)
- Zhongwei Wu (ORCID: https://orcid.org/0000-0002-4043-7624)
- Xiyu Wang (ORCID: https://orcid.org/0009-0002-7558-6504)
- Yang Bai (ORCID: https://orcid.org/0009-0002-6148-7433)
Institutions
- Hainan Normal University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Synthesis
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1055/a-2443-5162
- Citations
- 2
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- Natural Science Foundation of Liaoning Province
- Shanghai Municipal Commission of Agriculture and Rural Affairs
- Fundamental Research Funds for the Central Universities