Concise Synthesis of Tetrasubstituted 1,6-Dihydropyridazine and Pyridazine Derivatives
Abstract A novel one-pot three-steps process has been developed, including phosphine-catalyzed Rauhut–Currier reaction of γ-alkyl allenoates, Diels–Alder reaction with di-tert-butyl azodicarboxylate, followed by deprotection of Boc group to prepare tetra-substituted 1,6-dihydropyridazines in good yields. The 1,6-dihydropyridazines were easily converted to pyridazine derivatives via oxidative aromatization by DDQ.
Authors
- Weijun Yao (ORCID: https://orcid.org/0000-0001-6463-2937)
- Juan Zhang (ORCID: https://orcid.org/0000-0001-8688-5679)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-1165-2552)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0001-7766-2545)
Institutions
- Zhejiang Sci-Tech University (CN)
- Chongqing University (CN)
Publication Details
- Journal
- Synthesis
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1055/a-2445-1338
- Citations
- 4
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- Natural Science Foundation of Zhejiang Province