Computational approaches for identifications of altered ion channels in keratoconus
Down-regulation of voltage-gated calcium channels can be attributed to reduced cell proliferation and differentiation. Additionally, deregulated ion channels in 3',5'- cyclic adenosine monophosphate signalling may be responsible for elevated cortisol level in progressive keratoconus patients.
Authors
- Akhilesh Pandey (ORCID: https://orcid.org/0000-0001-9943-6127)
- Prema Padmanabhan (ORCID: https://orcid.org/0000-0001-7248-9907)
- Jyoti Sharma (ORCID: https://orcid.org/0000-0003-3299-9907)
- Jayavigneeswari Suresh Babu
- Kaushik Parthasarathi (ORCID: https://orcid.org/0000-0001-5615-9094)
- Narayanan Janakiraman (ORCID: https://orcid.org/0000-0003-0866-9828)
- Seetaramanjaneyulu Gundimeda (ORCID: https://orcid.org/0000-0001-9705-0159)
- Sailaja Elchuri (ORCID: https://orcid.org/0000-0002-9780-2717)
- Kiran Bharat Gaikwad
Institutions
- Sankara Nethralaya (IN)
- Mayo Clinic (US)
- Manipal Academy of Higher Education (IN)
- Mayo Clinic in Arizona (US)
- Institute of Bioinformatics (IN)
Publication Details
- Journal
- Eye
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1038/s41433-024-03395-5
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Department of Biotechnology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Council of Scientific and Industrial Research, India
- The Wellcome Trust DBT India Alliance