Development of new K<sub>ir</sub>2.1 channel openers from propafenone analogues
GPV0057 has a strong efficiency towards increasing I<sub>K1</sub>, which makes it a good candidate to address I<sub>K1</sub> deficiency-associated diseases.
Authors
- Joost P. G. Sluijter (ORCID: https://orcid.org/0000-0003-2088-9102)
- Encan Li (ORCID: https://orcid.org/0000-0002-2741-2289)
- Anna Stary‐Weinzinger (ORCID: https://orcid.org/0000-0002-9202-0484)
- Marcel A. G. van der Heyden (ORCID: https://orcid.org/0000-0002-4225-7942)
- Willem B. van Ham (ORCID: https://orcid.org/0000-0002-6621-148X)
- Gerhard Franz Ecker (ORCID: https://orcid.org/0000-0003-4209-6883)
- Renée G. C. Maas (ORCID: https://orcid.org/0000-0002-6607-4104)
- Marien J. C. Houtman (ORCID: https://orcid.org/0009-0007-9332-5160)
- Najla Boujeddaine
Institutions
- University of Vienna (AT)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1111/bph.17377
- Citations
- 3
- Primary Topic
- Metal and Thin Film Mechanics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- China Scholarship Council
- European Research Council