Exploring estrogen-related mechanisms in ovarian carcinogenesis: association between bone mineral density and ovarian cancer risk in a multivariable Mendelian randomization study
Our study found associations between genetic predisposition to higher BMD, a proxy for long-term estrogen exposure, and risk of developing endometroid and high-grade serous EOC cancers. These findings add to existing evidence of the relationship between estrogen and increased risk of EOC for certain histotypes.
Authors
- Karen Tuesley (ORCID: https://orcid.org/0000-0002-5944-5085)
- Penelope M. Webb (ORCID: https://orcid.org/0000-0003-0733-5930)
- Peter Donovan (ORCID: https://orcid.org/0000-0001-7934-601X)
- Suzanne C. Dixon‐Suen (ORCID: https://orcid.org/0000-0003-3714-8386)
- Melinda M. Protani (ORCID: https://orcid.org/0000-0001-6452-7571)
- Susan J. Jordan (ORCID: https://orcid.org/0000-0002-4566-1414)
Institutions
- Deakin University (AU)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- Cancer Council Victoria (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Royal Brisbane and Women's Hospital (AU)
Publication Details
- Journal
- Cancer Causes & Control
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1007/s10552-024-01926-9
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- University of Queensland
- National Health and Medical Research Council