Reduced circulating CD63+ extracellular vesicle levels associate with atherosclerosis in hypercholesterolaemic mice and humans
This research demonstrates an inverse relationship between circulating EVs and cholesterol, making EVs a potential marker for cardiovascular disease (CVD). HFD causes reduced cardiac function, but atherosclerotic development is slowly progressing in hypercholesterolaemic models and only observed with old animals. These results also bring further evidence for the benefit of using of PCSK9 inhibitors as therapeutic agents in CVD.
Authors
- Krisztína Németh (ORCID: https://orcid.org/0000-0002-3825-2137)
- Tamás G. Gergely (ORCID: https://orcid.org/0000-0003-1972-2065)
- Barbara W. Sódar
- Johannes Oesterreicher (ORCID: https://orcid.org/0000-0003-4899-3198)
- Nabil V. Sayour (ORCID: https://orcid.org/0000-0003-2236-2881)
- Péter Ferdinandy (ORCID: https://orcid.org/0000-0002-6424-6806)
- Xabier Osteikoetxea (ORCID: https://orcid.org/0000-0003-3628-0174)
- Wolfgang Holnthoner (ORCID: https://orcid.org/0000-0001-6425-9028)
- Zoltán V. Varga (ORCID: https://orcid.org/0000-0002-2758-0784)
- András I. Försönits
- Zoltán Giricz (ORCID: https://orcid.org/0000-0003-2036-8665)
- Edit I. Buzás (ORCID: https://orcid.org/0000-0002-3744-206X)
- Brachyahu Meir Kestecher (ORCID: https://orcid.org/0009-0000-5689-7548)
- Bernadett R. Bodnár (ORCID: https://orcid.org/0000-0003-3347-9225)
- S. Ghosal (ORCID: https://orcid.org/0000-0001-6618-930X)
Institutions
- Semmelweis University (HU)
- Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT)
- Montavid Thermodynamic Research Group (HU)
- Institute of Genetics (HU)
- Austrian Cluster for Tissue Regeneration (AT)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s12933-024-02459-w
- Citations
- 10
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- European Commission
- Hungarian Scientific Research Fund
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Horizon 2020 Framework Programme
- National Research, Development and Innovation Office