Dissociation of the nuclear WWOX/TRAF2 switch renders UV/cold shock-mediated nuclear bubbling cell death at low temperatures
The temperature-sensitive nuclear WWOX/TRAF2 complex acts as a molecular switch, whose dissociation favors BCD at low temperatures, and the association supports apoptosis at 37 °C in UV-treated WWOXf cells.
Authors
- Lu‐Hai Wang (ORCID: https://orcid.org/0000-0003-0050-8560)
- Nan‐Shan Chang (ORCID: https://orcid.org/0000-0002-6889-8756)
- Shenq‐Shyang Huang (ORCID: https://orcid.org/0000-0001-8476-3141)
- Cheng‐Chang Tsai
- Hongtao Zeng (ORCID: https://orcid.org/0000-0001-6587-6984)
- Sing-Ru Lin
- Ming‐Fu Chiang
- Hamm‐Ming Sheu
- Szu-Jung Chen
- Ming-Hui Lee
Institutions
- Fu Jen Catholic University (TW)
- China Medical University (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s12964-024-01866-6
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Ministry of Science and Technology, Taiwan
- National Health Research Institutes
- National Science and Technology Council