Detection of <i>Mycobacterium bovis</i> in Free‐Ranging <i>Sapajus nigritus</i>, Argentina
Mycobacterium bovis and Mycobacterium tuberculosis are the most relevant among pathogenic mycobacteria, both belonging to the M. tuberculosis complex (MTC). Samples of blood, liver, spleen, kidneys, lungs and caseous tubercles were collected from a free-ranging juvenile black capuchin monkey (Sapajus nigritus) showing non-specific signs of illness. Macroscopic findings included emaciation, a caseous lesion in a tooth and gingiva, disseminated nodules in both lungs and left kidney parenchyma and caseous nodules on the pleura and mesentery. The lesions suggested MTC infection, a diagnosis subsequently supported in the lung by bacilloscopy, immunochromatography and PCR. A multiplex PCR further validated the presence of M. bovis genes. Cases of tuberculosis in platyrrhine primates have only been reported in animals maintained in captivity. We describe for the first time the pathological and molecular findings of M. bovis infection in a free-ranging platyrrhine monkey within an area of intense human-wildlife interaction, which has important implications from a One Health perspective.
Authors
- Clara J. Scarry (ORCID: https://orcid.org/0000-0002-4288-4698)
- María Paula Tujague (ORCID: https://orcid.org/0000-0003-1829-4986)
- María Gabriela Cáceres
- María Jimena Marfil (ORCID: https://orcid.org/0000-0001-8134-7978)
- Natalia Sasoni
- Eduardo A. Lestani
- Esteban Couto (ORCID: https://orcid.org/0000-0002-4577-7142)
- Daniela Lamattina (ORCID: https://orcid.org/0000-0002-5926-8234)
- Dante Luis Di Nucci (ORCID: https://orcid.org/0000-0003-0633-3482)
- Noemí Pérez (ORCID: https://orcid.org/0000-0003-2420-6727)
- Oscar Daniel Salomón (ORCID: https://orcid.org/0000-0002-6206-3862)
- Angélica Kim
- Mariela Martínez (ORCID: https://orcid.org/0009-0000-7860-7513)
- Marcela López
- Juan Pablo Arrabal
- Rossana Piloni
- Carlos Zenobi
- Roberto Trigo
- Diego Bombelli
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- National University of Misiones (AR)
- Universidad de Buenos Aires (AR)
- Ministerio de Salud (AR)
- Administración Nacional de Laboratorios e Institutos de Salud (AR)
- Instituto de Biología Subtropical (AR)
- Instituto Nacional de Medicina Tropical (AR)
- National Food Safety and Quality Service (AR)
- California State University, Sacramento (US)
- Fundación de Historia Natural Félix de Azara
Publication Details
- Journal
- Zoonoses and Public Health
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1111/zph.13189
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas