Artemisinin-Quinidine Combination for Suppressing Ventricular Tachyarrhythmia in an Ex Vivo Model of Brugada Syndrome
Low-dose quinidine alone fails to fully alleviate VTA in the BrS wedge model. However, its combination with artemisinin effectively suppresses VTA. Artemisinin may reduce the therapeutic dose of quinidine, potentially minimizing its associated adverse effects.
Authors
- Hyung Ki Jeong (ORCID: https://orcid.org/0000-0001-5749-9525)
- Namsik Yoon (ORCID: https://orcid.org/0000-0001-9112-150X)
- Ki Hong Lee (ORCID: https://orcid.org/0000-0002-9938-3464)
- Yoo Ri Kim (ORCID: https://orcid.org/0000-0001-7351-1299)
- Hyung Wook Park (ORCID: https://orcid.org/0000-0002-9630-0467)
Institutions
- Chonnam National University Hospital (KR)
- Wonkwang University (KR)
Publication Details
- Journal
- Journal of Korean Medical Science
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3346/jkms.2025.40.e2
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea