The divergent outcome of IL-4Rα signalling on Foxp3 T regulatory cells in listeriosis and tuberculosis
Our results demonstrated that the diminished IL-4Rα signalling on Foxp3+ T regulatory cells resulted in a loss of their functionality, leading to survival benefits in listeriosis but not in tuberculosis.
Authors
- Rodney Lucas
- Suraj P. Parihar (ORCID: https://orcid.org/0000-0002-4932-7990)
- Sibongiseni K. L. Poswayo
- Frank Brombacher (ORCID: https://orcid.org/0000-0001-8881-6781)
- Julius Ebua Chia (ORCID: https://orcid.org/0000-0001-5786-5580)
- Mumin Ozturk (ORCID: https://orcid.org/0000-0001-9152-7614)
- Robert P. Rousseau (ORCID: https://orcid.org/0000-0003-1620-1600)
Institutions
- University of Cape Town (ZA)
- North-West University (ZA)
- International Centre for Genetic Engineering and Biotechnology (ZA)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3389/fimmu.2024.1427055
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Wellcome Trust