Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics
No association of metabolizing enzyme variants with ezetimibe pharmacokinetic parameters was found. The results show some trends in the univariate analysis for <i>ABCB1</i> rs2032582 or <i>ABCC2</i> rs2273697 and C<sub>max</sub> (<i>p univariate</i> (<i>p</i> <sub><i>uv</i></sub> ) = 0.056 and 0.087, respectively), which finally reach significance in the multivariate analysis (<i>p multivariate</i> (<i>p</i> <sub><i>mv</i></sub> ) = 0.049 and 0.048, respectively). Nevertheless, these results need to be validated in future studies.
Authors
- Eva González‐Iglesias (ORCID: https://orcid.org/0000-0003-4875-6141)
- Francisco Abad‐Santos (ORCID: https://orcid.org/0000-0002-6519-8885)
- Paula Soria‐Chacartegui (ORCID: https://orcid.org/0000-0002-1951-2626)
- Pablo Zubiaur (ORCID: https://orcid.org/0000-0002-6150-4320)
- Marcos Navares‐Gómez (ORCID: https://orcid.org/0000-0003-2501-6845)
- Andrea Rodríguez‐Lopez
- Jesús Novalbos (ORCID: https://orcid.org/0000-0001-5384-4512)
- Marina Aldama
- Dolores Ochoa
- Tamara de la Torre
- Marta de los Ríos-Rodríguez
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital Universitario de La Princesa (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3389/fphar.2024.1414059
- Citations
- 4
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Instituto de Salud Carlos III