β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction
These results suggest that β-elemene effectively modulates radioresistance in GC by targeting the GPX4 pathway and inducing ferroptosis. This highlights its potential as a therapeutic adjunct in radiotherapy for resistant GC cases.
Authors
- Yifeng Peng (ORCID: https://orcid.org/0000-0002-1273-8171)
- Jiancheng He
- Junjie Chen (ORCID: https://orcid.org/0000-0002-3258-0236)
- Wanjiang Xue (ORCID: https://orcid.org/0000-0002-0137-7331)
- Jun Zhao
- Jiapeng Bao
- Ming Li (ORCID: https://orcid.org/0009-0002-3553-6932)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3389/fphar.2024.1469180
- Citations
- 18
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Nantong University