Characterization of GABAergic marker expression in prefrontal cortex in dexamethasone induced depression/anxiety model
Our results indicate that a reduction in the number of GABAergic interneurons may result in deficiencies in cortical inhibitory neurotransmission, potentially causing an E/I imbalance in the PFC; this insight suggests a potential breakthrough strategy for the treatment of depression and anxiety.
Authors
- Miaoxin Qiu
- Zhufang Shen (ORCID: https://orcid.org/0000-0003-0690-015X)
- Guangchao Liu (ORCID: https://orcid.org/0000-0002-9078-8019)
- W Wang
- S. Liu (ORCID: https://orcid.org/0009-0006-0902-0149)
- Shiwei Liu (ORCID: https://orcid.org/0000-0002-0396-9883)
- Xiaoqi Liu (ORCID: https://orcid.org/0000-0003-2682-0261)
- Xiaoqing Wang (ORCID: https://orcid.org/0000-0002-5289-040X)
- Na Fang (ORCID: https://orcid.org/0000-0003-1789-3792)
- Ling Hu (ORCID: https://orcid.org/0000-0003-1143-1458)
- Wenjuan Fan (ORCID: https://orcid.org/0000-0002-2927-9266)
- Yafei Zheng (ORCID: https://orcid.org/0000-0002-7062-5271)
- Z. Jiao (ORCID: https://orcid.org/0000-0002-4774-5961)
Institutions
- Tongji University (CN)
- Henan University (CN)
- Fudan University (CN)
- Luohe Medical College (CN)
- Tongji Hospital (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3389/fendo.2024.1433026
- Citations
- 7
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- National Natural Science Foundation of China
- Henan University
- Natural Science Foundation of Henan Province