Characterization of ligand-receptor pair in acute myeloid leukemia: a scoring model for prognosis, therapeutic response, and T cell dysfunction
qRT-PCR analysis on AML versus normal bone marrow samples confirmed the significant downregulation of CLEC11A, ITGA4, ICAM4, and AVP in AML, suggesting their inverse biomarker potential in AML. In summary, this study illuminates the significance of the LR pair network in predicting AML prognosis, offering avenues for more precise treatment strategies tailored to individual patient profiles.
Authors
- Shaobo Ni
- Xin Jin (ORCID: https://orcid.org/0000-0001-6461-6005)
- Mei Zhou
- Chunlan Fu (ORCID: https://orcid.org/0009-0002-0615-6308)
- Di Qiu (ORCID: https://orcid.org/0000-0003-0325-6813)
Institutions
- Wenzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3389/fonc.2024.1473048
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00