FGF-2 enriched nanofiber scaffold for advancing achilles tendon healing: a comparative experimental investigation
FGF-2 coated scaffolds significantly enhanced tendon healing in a rat Achilles tendon rupture model by improving fibril organization, increasing vascularity, and reducing inflammation and pathological adipogenesis. These findings suggest that FGF-2 could be a promising therapeutic option for accelerating tendon repair. Future perspectives on tendon repair will focus on enhancing FGF-2 delivery using innovative scaffolds, paving the way for more effective therapies and improved patient outcomes.
Authors
- Nimet Turgut (ORCID: https://orcid.org/0000-0001-6446-2958)
- Halil Aşçı (ORCID: https://orcid.org/0000-0002-1545-035X)
- Meriç Ünal (ORCID: https://orcid.org/0000-0001-9576-5994)
- Kanat Gülle (ORCID: https://orcid.org/0000-0002-6337-8962)
- Mehtap Savran (ORCID: https://orcid.org/0000-0002-7933-0453)
- Funda Cengiz Çallıoğlu (ORCID: https://orcid.org/0000-0002-6614-3616)
- Aytül Bayraktar
Institutions
- Süleyman Demirel Üniversitesi (TR)
- Başkent University (TR)
- Suleyman Demirel University (KZ)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3389/fsurg.2024.1424734
- Citations
- 2
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Süleyman Demirel Üniversitesi