Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice
DPAL reduces thrombogenesis with minimal effects on bleeding in mouse models via selective binding to PS. DPAL may support novel approaches to modulate pathogenic thrombin generation with improved safety profiles in multiple contexts.
Authors
- Victor Rizzo (ORCID: https://orcid.org/0000-0002-5705-5462)
- Lawrence E. Goldfinger (ORCID: https://orcid.org/0000-0003-0525-6008)
- Xuefei Zhao (ORCID: https://orcid.org/0000-0002-8651-6248)
- Fabiola Del Carpio‐Cano
- Brian D. Gray
- Jeremy G. T. Wurtzel
- Parkson Lee‐Gau Chong (ORCID: https://orcid.org/0000-0002-1378-5244)
- Koon Y. Pak (ORCID: https://orcid.org/0000-0001-5440-7576)
- Peisong Ma (ORCID: https://orcid.org/0000-0002-5486-8695)
- Steven E. McKenzie (ORCID: https://orcid.org/0000-0003-2654-8560)
- A. Koneti Rao
- Michelle Tanujaya
Institutions
- Thomas Jefferson University (US)
- Molecular Targeting Technologies (United States) (US)
- Temple University (US)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1016/j.jtha.2024.10.007
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- American Heart Association
- W. W. Smith Charitable Trust
- National Institutes of Health
- National Heart, Lung, and Blood Institute