Systemic Sclerosis Dermal Fibroblast Exosomes Trigger Type 1 Interferon Responses in Keratinocytes via a <scp>TBK</scp> / <scp>JAK</scp> / <scp>STAT</scp> Signaling Axis
IFN activation of SSc keratinocytes is dependent on their crosstalk with dermal fibroblasts and inducible by extracellular exosomes. Our data indicate that SSc fibroblast exosomes contribute to the type I IFN activation in SSc skin through activation of pattern recognition receptors upstream of TBK.
Authors
- Elton Zeqiraj (ORCID: https://orcid.org/0000-0003-0239-5926)
- Katja Koeppen (ORCID: https://orcid.org/0000-0003-1094-0621)
- Christopher W. Wasson (ORCID: https://orcid.org/0000-0001-6558-4738)
- Leon F. Willis (ORCID: https://orcid.org/0000-0001-6616-3716)
- Francesca Chandler (ORCID: https://orcid.org/0000-0003-3465-7599)
- Jessica Bryon
- Francesco Del Galdo (ORCID: https://orcid.org/0000-0002-8528-2283)
- Stefano Di Donato (ORCID: https://orcid.org/0000-0003-2396-2061)
- Elliott Klein
- Rebecca L. Ross (ORCID: https://orcid.org/0000-0001-7750-4280)
Institutions
- University of Leeds (GB)
- Boehringer Ingelheim (Brazil) (BR)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- Institute of Structural and Molecular Biology (GB)
- Boehringer Ingelheim (United States) (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1002/art.43029
- Citations
- 13
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.52
Funders
- Medical Research Council