Copper(II)‐Catalyzed Regioselective H/D Exchange Based on Reversible C−H Activation
Despite the increasing use of copper in C-H functionalizations, the Cu-catalyzed direct deuteration of C-H bonds remains a significant challenge due to its inherent low reactivity in inverse C-H bond reconstruction. In this paper, a novel strategy had been developed to reverse the copper-catalyzed concerted metalation-deprotonation process by inhibiting the unexpected disproportionation of Cu(II) to Cu(III). Picolinic acid was identified as a powerful ligand for facilitating this H/D exchange with D<sub>2</sub>O as deuterium source, and its inhibition activity was supported by preliminary control experiments and DFT studies.
Authors
- Lijie Duan (ORCID: https://orcid.org/0000-0001-8027-0382)
- Jian‐Fei Bai (ORCID: https://orcid.org/0000-0002-9128-5819)
- Zhanghua Gao (ORCID: https://orcid.org/0000-0002-6950-8609)
- Zhi‐Jiang Jiang (ORCID: https://orcid.org/0000-0003-2323-1840)
- Jia Chen (ORCID: https://orcid.org/0000-0003-1541-2617)
- Jiawei Han (ORCID: https://orcid.org/0009-0002-6646-2753)
- Yuhang Su
Institutions
- Ningbo University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1002/chem.202403121
- Citations
- 4
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.83
Funders
- National Natural Science Foundation of China
- Ningbo Municipal Bureau of Science and Technology
- Natural Science Foundation of Ningbo