Predictors of Persistent Prostate-Specific Antigen Persistence after Radical Prostatectomy

<b><i>Objective:</i></b> To investigate the predictors of persistent prostate-specific antigen (PSA) after radical prostatectomy (RP). <b><i>Methods:</i></b> From January 2019 to December 2022, 212 patients with prostate cancer who underwent RP were retrospectively analyzed. According to the PSA value at 4-8 weeks postoperatively, the patients were divided into the PSA <0.1 ng/mL group (<i>n</i> = 142) and PSA ≥0.1 ng/mL group (<i>n</i> = 70). Logistic regression was used to analyze the independent risk factors of persistent PSA, and the logistic regression equation was established to predict the probability of persistent PSA. <b><i>Results:</i></b> Total PSA (tPSA) levels at diagnosis >49.73 ng/mL, free PSA (fPSA) levels at diagnosis >2.07 ng/mL, or clinical T stage >T3a were independent risk factors for PSA persistence after RP. <b><i>Conclusion:</i></b> Patients with tPSA at diagnosis >49.73 ng/mL, fPSA at diagnosis >2.07 ng/mL, and T3b prostate cancer showed strong associations with persistent PSA.