Nanoparticle-Directed Antioxidant Therapy Can Ameliorate Disease Progression in a Novel, Diet-Inducible Model of Coronary Artery Disease
The SR-B1ΔCT/LDLR<sup>-/-</sup> mice developed diet-inducible, fatal atherosclerotic coronary artery disease, which could be ameliorated by targeted nanoparticle therapy. Our study provides new tools for the development of cardiovascular therapies.
Authors
- Monty Krieger (ORCID: https://orcid.org/0000-0003-4541-5181)
- Shi Su (ORCID: https://orcid.org/0000-0001-6848-2817)
- Olivier Kocher (ORCID: https://orcid.org/0009-0001-0686-9095)
- Zhifen Chen (ORCID: https://orcid.org/0000-0002-1622-2105)
- Peter M. Kang (ORCID: https://orcid.org/0000-0002-7200-4567)
- Qingen Ke (ORCID: https://orcid.org/0000-0002-6296-4521)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Center for Vascular Biology Research (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1161/atvbaha.124.321030
- Citations
- 4
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Harvard Catalyst