Effectiveness and Safety of Low-Dose Etoposide Chemomobilization in Patients with Multiple Myeloma and Lymphoma

Studies have discovered a risk of treatment-related leukemia and myelodysplastic syndromes with high doses of etoposide prompting a closer look, at the effectiveness of lower doses. In this study, we aimed to demonstrate the efficacy of low-dose etoposide in patients with MM and lymphoma. Forty-eight patients with MM and refractory lymphoma who underwent stem cell mobilization with low-dose etoposide (days 1 and 2, 375 mg/m²) and granulocyte colony-stimulating factor (G-CSF, 10-15 μg/kg after the 3rd day) in Bursa Uludağ University Faculty of Medicine Hematology Department Stem Cell Transplantation Unit were analyzed retrospectively. The rate of successful mobilization (> 2x106/kg CD34+ cell collection) was 95% and was performed in a minimum of 1 and a maximum of 3 apheresis. The median collected CD34+ cell count was 9.165 × 10⁶/kg (11.7 in good vs 3.98 in poor mobilizers, p