Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

H3K9 lactylation promotes M1 polarization and inflammation via the TNF pathway, identifying it as a potential therapeutic target for neonatal HIE.

Authors

Weijian Hang (ORCID: https://orcid.org/0000-0002-7277-2929)
Jinli Han (ORCID: https://orcid.org/0000-0002-7645-5875)
Bin Wen (ORCID: https://orcid.org/0000-0001-9846-5452)
Juan Chen (ORCID: https://orcid.org/0000-0001-5801-9124)
Ling Chen (ORCID: https://orcid.org/0000-0003-1485-1626)
Lu He (ORCID: https://orcid.org/0000-0002-7367-2452)
Rui Yin (ORCID: https://orcid.org/0009-0006-0496-8440)

Institutions

Shanxi Medical University (CN)
Shanxi Academy of Medical Sciences (CN)
Tongji Hospital (CN)
Huazhong University of Science and Technology (CN)

Publication Details

Journal: Biomedicines
Published: 2024-10-17
DOI: https://doi.org/10.3390/biomedicines12102371
Citations: 15
Primary Topic: Neuroinflammation and Neurodegeneration Mechanisms
Type: article
Field-Weighted Citation Impact: 3.71

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article

Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

Weijian Hang, Jinli Han, Bin Wen, Juan Chen et al.

Oct 17, 2024

15 citations

Biomedicines

Neuroinflammation and Neurodegeneration Mechanisms

3.71

article

Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

Weijian Hang, Jinli Han, Bin Wen, Juan Chen, Ling Chen, Lu He, Rui Yin

October 17, 2024article en

15 citations

Abstract

H3K9 lactylation promotes M1 polarization and inflammation via the TNF pathway, identifying it as a potential therapeutic target for neonatal HIE.

BiomedicinesVol. 12(10)

Shanxi Medical University (CN), Shanxi Academy of Medical Sciences (CN), Tongji Hospital (CN), Huazhong University of Science and Technology (CN)

Openalex Percentile: Top 6%

Neuroinflammation and Neurodegeneration Mechanisms

3.71

DOI Open Access PDF OpenAlex

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Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway — Weijian Hang, Jinli Han, et al. · Biomedicines (2024) | TGRS Research Map | TGRS