In vivo imaging of the human brain with the Iseult 11.7-T MRI scanner
The understanding of the human brain is one of the main scientific challenges of the twenty-first century. In the early 2000s, the French Atomic Energy Commission launched a program to conceive and build a human magnetic resonance imaging scanner operating at 11.7 T. We have now acquired human brain images in vivo at such a magnetic field. We deployed parallel transmission tools to mitigate the radiofrequency field inhomogeneity problem and tame the specific absorption rate. The safety of human imaging at such high field strength was demonstrated using physiological, vestibular, behavioral and genotoxicity measurements on the imaged volunteers. Our technology yields T<sub>2</sub> and T<sub>2</sub><sup>*</sup>-weighted images reaching mesoscale resolutions within short acquisition times and with a high signal and contrast-to-noise ratio.
Authors
- Caroline Le Ster (ORCID: https://orcid.org/0000-0002-4767-8738)
- Michel Bottlaender (ORCID: https://orcid.org/0000-0002-2890-3653)
- Alexis Amadon (ORCID: https://orcid.org/0000-0002-2667-9387)
- Franck Mauconduit (ORCID: https://orcid.org/0000-0002-0128-061X)
- Christophe Pallier (ORCID: https://orcid.org/0000-0002-3324-666X)
- Nicolas Boulant (ORCID: https://orcid.org/0000-0003-2144-2484)
- Laure Sabatier (ORCID: https://orcid.org/0000-0003-0552-6549)
- Denis Le Bihan
- Michel Luong
- Aurélien Massire (ORCID: https://orcid.org/0000-0002-4621-8254)
- Alexandre Vignaud
- Vincent Gras
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Direction des Energies (FR)
- CEA Paris-Saclay (FR)
- Siemens (France) (FR)
- Cognitive Neuroimaging Lab (FR)
Publication Details
- Journal
- Nature Methods
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1038/s41592-024-02472-7
- Citations
- 45
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 18.19
Funders
- Bpifrance
- Equipex
- Agence Nationale de la Recherche
- Horizon 2020 Framework Programme