Risk factors and clinical significance of post‐stroke incident ischemic lesions
Incident ischemic lesions (IILs) were assessed with registered baseline and 6-month magnetic resonance imaging (MRI) scans in a stroke cohort. IILs 6 months after stroke are present in one-sixth of patients and are mostly clinically silent. Small vessel disease burden is the main baseline risk factor for IILs. IILs are associated with cognitive and functional impairment and stroke recurrence. Assessing IILs by follow-up MRI aids long-term prognostication for stroke patients.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Matthias Endres (ORCID: https://orcid.org/0000-0001-6520-3720)
- Inga Zerr (ORCID: https://orcid.org/0000-0002-6722-2463)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Gabor C. Petzold (ORCID: https://orcid.org/0000-0002-0145-8641)
- Christian H. Nolte (ORCID: https://orcid.org/0000-0001-5577-1775)
- Benno Ikenberg (ORCID: https://orcid.org/0000-0002-0798-7149)
- Anna Dewenter (ORCID: https://orcid.org/0000-0002-5636-196X)
- Felix J. Bode (ORCID: https://orcid.org/0000-0003-4498-186X)
- Lucia Kerti (ORCID: https://orcid.org/0000-0002-2383-7909)
- Michael Wagner (ORCID: https://orcid.org/0000-0003-2589-6440)
- Kathleen Bernkopf
- Sebastian Stösser (ORCID: https://orcid.org/0000-0002-1182-705X)
- Oliver Speck (ORCID: https://orcid.org/0000-0002-6019-5597)
- Marios K. Georgakis (ORCID: https://orcid.org/0000-0003-3507-3659)
- Karin Waegemann
- Martin Dichgans (ORCID: https://orcid.org/0000-0002-0654-387X)
- Rong Fang (ORCID: https://orcid.org/0000-0002-5663-9407)
- Thomas Liman (ORCID: https://orcid.org/0000-0002-8471-8049)
- Daniel Janowitz (ORCID: https://orcid.org/0009-0003-4090-547X)
- Benno Gesierich (ORCID: https://orcid.org/0000-0003-2842-7105)
- Péter Hermann (ORCID: https://orcid.org/0000-0003-1889-8325)
- Silke Wunderlich (ORCID: https://orcid.org/0000-0003-1208-3686)
- Wenzel Glanz (ORCID: https://orcid.org/0000-0002-5865-4176)
- Marco Duering (ORCID: https://orcid.org/0000-0003-2302-3136)
- Julius N. Meißner (ORCID: https://orcid.org/0000-0002-8980-9337)
- Michael Görtler
- Katja Neumann
Institutions
- Broad Institute (US)
- Carl von Ossietzky Universität Oldenburg (DE)
- University of Basel (CH)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- TUM Klinikum (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Universitätsmedizin Göttingen (DE)
- Center for Behavioral Brain Sciences (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Technical University of Munich (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Leibniz Institute for Neurobiology (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1002/alz.14274
- Citations
- 10
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 3.87
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Corona-Stiftung
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- Bundesministerium für Bildung und Forschung
- Gemeinnützige Hertie-Stiftung
- Deutsches Zentrum für Neurodegenerative Erkrankungen