Comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban in dogs
Repeated PO administration of apixaban or rivaroxaban to healthy dogs produced comparable anticoagulant effects measured by inhibition of thrombin formation. Rebound hypercoagulability after drug discontinuation was not observed and weaning of these drugs in clinical patients might not be necessary.
Authors
- Laura K. Ruterbories
- Alex Lynch (ORCID: https://orcid.org/0000-0002-8747-094X)
- Mark G. Papich (ORCID: https://orcid.org/0000-0002-7591-7898)
- Marjory B. Brooks (ORCID: https://orcid.org/0000-0001-5489-9013)
- Robert Goggs (ORCID: https://orcid.org/0000-0001-7446-6987)
- Yao Zhu
- Frank Fialkiewicz
Institutions
- North Carolina State University (US)
- University of Georgia (US)
- Cornell University (US)
- North Central State College (US)
- New York State College of Veterinary Medicine (US)
Publication Details
- Journal
- Journal of Veterinary Internal Medicine
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1111/jvim.17216
- Citations
- 4
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- American Veterinary Medical Foundation