Comparison of Plasma Corin Levels in Gestational Hypertensive Patients, Normotensive Pregnant and Normotensive Non-Pregnant Women

Background: Multiple factors play role in gestational hypertension including vasopressin production and Renin-angiotensin-aldosterone system activation. Opposing these effects, corin plays an important role in mediating natriuretic peptide biosynthesis cascade which is an important factor in regulating fluid balance and blood pressure. Corin levels have been studied in relation to gestational hypertension and results were controversial.Objective:: This study aimed at comparing plasma corin levels in gestational hypertensive patients, normotensive pregnant women, and normotensive non-pregnant women.Methods: This was a cross sectional comparative study conducted for one year at Shaikh Zayed Medical Complex. By convenient sampling, ninety women aged 18-45 years were included; thirty pregnant (primigravida and multigravida) with gestational hypertension, thirty pregnant (primigravida and multigravida) normotensive women, and thirty non-pregnant normotensive women. Patients with gestational diabetes, renal diseases, hypertension before pregnancy, and other cardiovascular diseases were excluded. Informed consent was taken and demographic data was recorded. Three ml of blood was taken from each participant and corin levels were measured using ELISA kit. Data was analysed using SPSS 24.Results: A significant difference was found in BMI among the three groups with the gestational hypertensive patients having the highest BMI (p-value < 0.05). There was no significant difference in gravid and parity count between gestational hypertensive patients and pregnant normotensive women. No significant difference was found in corin levels among the three groups and there was no significant correlation between corin levels and age nor between corin levels and BMI.Conclusion: There is no significant difference in plasma corin levels amongst gestational hypertensive patients, normotensive pregnant women, and normotensive non-pregnant women.