Growth differentiation factor 11 alleviates oxidative stress-induced senescence of endothelial progenitor cells via activating autophagy
This study provides novel evidence suggesting that oxidative stress could induce senescence of the transplanted EPCs in the ischemic myocardium. GDF11 demonstrates the ability to mitigate oxidative stress-induced senescence in the transplanted EPCs within the myocardium by activating autophagy.
Authors
- Hai‐jie Wang (ORCID: https://orcid.org/0000-0002-1783-9617)
- Ping Tao
- Pei Zhou (ORCID: https://orcid.org/0000-0003-1631-3637)
- Haifeng Zhang
- Yu‐zhen Tan (ORCID: https://orcid.org/0000-0001-7848-2132)
- Yongli Wang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Yunnan University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s13287-024-03975-y
- Citations
- 7
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.07
Funders
- National Natural Science Foundation of China