Impact of SCN10A Polymorphism on Abdominal Pain Perception and Visceral Hypoalgesia in Crohn's Disease and Ulcerative Colitis
These findings indicate that Na v 1.8 plays a key role in human visceral pain perception, and could serve as a novel diagnostic target in the management of hypoalgesic CD and UC, and potential therapeutic target for conditions associated with chronic abdominal pain.
Authors
- Kofi Clarke (ORCID: https://orcid.org/0000-0001-6956-155X)
- August Stuart
- Jeffrey Small
- Nurgul Carkaci‐Salli (ORCID: https://orcid.org/0000-0002-9335-5956)
- Kent E. Vrana (ORCID: https://orcid.org/0000-0003-4902-7733)
- Andrew Tinsley (ORCID: https://orcid.org/0000-0002-4153-918X)
- Víctor Ruiz-Velasco (ORCID: https://orcid.org/0000-0003-3614-5028)
- Matthew Coates (ORCID: https://orcid.org/0000-0001-8976-5015)
- Shannon Dalessio
- Vonn Walter (ORCID: https://orcid.org/0000-0001-6114-6714)
- Piotr Janicki
- Ann Ouyang
- Emmanuelle Williams
Institutions
- Pennsylvania State University (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.14309/ctg.0000000000000778
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.46
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases