Myocardial disarray and fibrosis across hypertrophic cardiomyopathy stages associate with ECG markers of arrhythmic risk
Low diastolic FA, suggestive of myocardial disarray, is present in both SARC+LVH- and HCM. Low FA and raised ECV were associated with repolarization prolongation. Myocardial disarray assessment using DT-CMR and repolarization parameters such as the JTc interval demonstrate significant potential as markers of disease activity in HCM.
Authors
- Prashanth Murthy (ORCID: https://orcid.org/0000-0001-5455-7793)
- Rina Ariga
- Betty Raman (ORCID: https://orcid.org/0000-0002-1239-9608)
- Hugh Watkins (ORCID: https://orcid.org/0000-0002-5287-9016)
- Kate Thomson (ORCID: https://orcid.org/0000-0003-2807-3431)
- Gloria E. Sarto
- Eleanor Wicks (ORCID: https://orcid.org/0000-0003-1086-6185)
- Elizabeth M. Tunnicliffe (ORCID: https://orcid.org/0000-0002-6945-5201)
- Niklas Beyhoff (ORCID: https://orcid.org/0000-0001-9140-2336)
- Lucy Finnigan (ORCID: https://orcid.org/0000-0003-3213-6845)
- Stefan Neubauer (ORCID: https://orcid.org/0000-0001-9017-5645)
- Zakariye Ashkir
- Masliza Mahmod (ORCID: https://orcid.org/0000-0002-0601-3510)
- Mark Philip Cassar (ORCID: https://orcid.org/0000-0001-7192-6917)
- Stephen Jermy (ORCID: https://orcid.org/0000-0001-7045-3863)
- A A Samat
- Barbara Wong
- M. A. Akhtar
Institutions
- University of Cape Town (ZA)
- University Kebangsaan Malaysia Medical Centre (MY)
- University of Oxford (GB)
- Oxford University Hospitals NHS Trust (GB)
- Resonance Research (United States) (US)
- National University of Malaysia (MY)
Publication Details
- Journal
- European Heart Journal - Cardiovascular Imaging
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1093/ehjci/jeae260
- Citations
- 6
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Universiti Kebangsaan Malaysia
- BHF Centre of Research Excellence, Oxford
- NIHR Oxford Biomedical Research Centre