Targeting the Leloir Pathway with Galactose-Based Antimetabolites in Glioblastoma
A functional Gal-scavenging pathway in GBM allows Gal-based antimetabolites to act as chemotherapeutics. 4DFG is metabolized by GBM in vitro and in vivo, is lethal to GBM tumors, and is well tolerated in mice.
Authors
- Brianna N. Baskin
- Martyn A. Sharpe (ORCID: https://orcid.org/0000-0002-2450-564X)
- Omkar B. Ijare (ORCID: https://orcid.org/0000-0003-1855-8232)
- Alexandra M. Baskin
- Sudhir Raghavan (ORCID: https://orcid.org/0000-0001-5449-362X)
- David S. Baskin (ORCID: https://orcid.org/0000-0002-8076-382X)
Institutions
- Houston Methodist (US)
- Cornell University (US)
- Methodist Hospital (US)
Publication Details
- Journal
- Cancers
- Published
- 2024-10-17
- DOI
- https://doi.org/10.3390/cancers16203510
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57