Adenomatoid Odontogenic Tumor: A 33-Year Retrospective Study with SEM Insight

Abstract Objective: This retrospective observational study aims to evaluate cases of adenomatoid odontogenic tumors (AOTs) from 1990 to 2023, including unique environmental scanning electron microscopy (ESEM) features. Study Design: Cases of AOT were retrieved from the Oral Pathology department archives and evaluated retrospectively over a 33-year period (1990–2023). Data collected and analyzed included age, sex, occupation, location, clinical features, radiographic appearance, and histopathological characteristics. Additional analysis was performed using ESEM. Results: Among the 4 cases evaluated, a majority demonstrated female occurrence and were most located in the mandibular region. ESEM analysis revealed distinctive structural features of AOT. Conclusion: This long-term study confirms the female predilection of AOT and identifies the mandible as the most common site of occurrence. SEM findings provide novel insights into the tumor’s ultrastructure, potentially aiding in diagnosis and understanding of AOT pathogenesis.