Spatial mapping of the HCC landscape identifies unique intratumoral perivascular-immune neighborhoods
Immune cell neighborhood interactions, but not cell densities, differ between intratumoral and adjacent nontumor regions in HCC. Unique intratumoral immune neighborhoods around the perivascular space point to an altered landscape within tumors. Enrichment of VEGFA+ perivascular macrophages within these tumors could play a key role in angiogenesis and vascular permeability.
Authors
- Thomas M. Ashhurst (ORCID: https://orcid.org/0000-0001-7269-7773)
- Charbel Sandroussi (ORCID: https://orcid.org/0009-0005-1644-8170)
- Felix Marsh‐Wakefield (ORCID: https://orcid.org/0000-0002-6839-7628)
- Givanna Putri (ORCID: https://orcid.org/0000-0002-7399-8014)
- Joo‐Shik Shin (ORCID: https://orcid.org/0000-0001-7840-3625)
- Carlo Pulitanò (ORCID: https://orcid.org/0000-0002-4420-4107)
- Michael Crawford (ORCID: https://orcid.org/0000-0001-7779-4636)
- Fiona H. X. Guan
- Jerome Laurence (ORCID: https://orcid.org/0000-0002-1123-0122)
- Angela L. Ferguson (ORCID: https://orcid.org/0000-0001-5974-0423)
- Cositha Santhakumar (ORCID: https://orcid.org/0000-0003-4126-497X)
- Geoffrey W. McCaughan (ORCID: https://orcid.org/0000-0002-1483-1636)
- Nicholas J. Shields (ORCID: https://orcid.org/0000-0003-2990-0478)
- Ruta Gupta (ORCID: https://orcid.org/0000-0003-2940-313X)
- Umaimainthan Palendira (ORCID: https://orcid.org/0000-0002-1113-3306)
- Ken Liu (ORCID: https://orcid.org/0000-0002-0453-3168)
- Barry J. Platt
Institutions
- The University of Sydney (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Royal Prince Alfred Hospital (AU)
- Centenary Institute (AU)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1097/hc9.0000000000000540
- Citations
- 4
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Cancer Institute NSW
- University of Sydney