High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition
High-glucose conditions aggravated the inflammatory response to P. gingivalis infection by suppressing of autophagy, suggesting that autophagy induction could potentially to treat periodontitis in diabetes. Zingerone has potential use as a treatment for periodontal inflammation induced by P. gingivalis in diabetes patients.
Authors
- Jin Chung (ORCID: https://orcid.org/0000-0001-9990-3768)
- Yuri Song (ORCID: https://orcid.org/0000-0002-6999-3851)
- Hee Sam Na (ORCID: https://orcid.org/0000-0002-3246-4681)
- Jin‐Ju Kwon (ORCID: https://orcid.org/0000-0002-3522-590X)
- Si Yeong Kim (ORCID: https://orcid.org/0000-0002-8438-8115)
- Sang‐Hun Shin (ORCID: https://orcid.org/0000-0002-0467-6206)
Institutions
- Pusan National University Dental Hospital (KR)
- Yeungnam University College
- Pusan National University (KR)
- Yeungnam University (KR)
Publication Details
- Journal
- BMC Immunology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s12865-024-00655-7
- Citations
- 6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea