Acceptability, validity and responsiveness of inertial measurement units for assessing motor recovery after gene therapy in infants with early onset spinal muscular atrophy: a prospective cohort study
IMUs were well accepted, consistent, concurrently valid, responsive and associated with unaided sitting acquisition especially for the elbow sensors. This study is the first reporting a large set of inertial sensor derived data after GT in SMA patients and paves the way for IMU-based follow-up of SMA patients after treatment.
Authors
- Damien Ricard
- Rémi Barrois (ORCID: https://orcid.org/0000-0001-8877-5035)
- V. Leloup-Germa
- E. Deladrière
- Nicolas Vayatis
- Sylvain Brochard (ORCID: https://orcid.org/0000-0002-4950-1696)
- Christine Barnérias (ORCID: https://orcid.org/0000-0003-3633-7273)
- Cyril Gitiaux (ORCID: https://orcid.org/0000-0002-2190-6843)
- Brian Tervil (ORCID: https://orcid.org/0000-0002-7275-2717)
- Laurent Oudre (ORCID: https://orcid.org/0000-0002-4750-2265)
- S Roy (ORCID: https://orcid.org/0000-0003-2091-0688)
- Marine Cacioppo (ORCID: https://orcid.org/0000-0001-8911-5645)
- I. Desguerre
- A Herve
- Pierre Paul Vidal
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Service de Santé des Armées (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Hospital of Geneva (CH)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- Hôpital Raymond-Poincaré (FR)
- Hôpital d'instruction des Armées Percy (FR)
- Laboratoire de Traitement de l'Information Médicale (FR)
Publication Details
- Journal
- Journal of NeuroEngineering and Rehabilitation
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s12984-024-01477-9
- Citations
- 5
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 2.19
Funders
- Agence Nationale de Sécurité du Médicament et des Produits de Santé