Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder
Receipt of methadone was associated with a lower risk of treatment discontinuation compared with buprenorphine/naloxone. The risk of mortality while receiving treatment was similar for buprenorphine/naloxone and methadone, although the CI estimate for the hazard ratio was wide.
Authors
- Micah Piske
- Paxton Bach (ORCID: https://orcid.org/0000-0002-2413-9133)
- Uwe Siebert (ORCID: https://orcid.org/0000-0001-6425-7671)
- Brenda Carolina Guerra‐Alejos
- Kyle M. Kampman (ORCID: https://orcid.org/0000-0002-9760-8324)
- Jeong Eun Min
- P. Todd Korthuis (ORCID: https://orcid.org/0000-0001-5556-3597)
- M. Eugenia Socías (ORCID: https://orcid.org/0000-0003-2556-7049)
- Mohammad Ehsanul Karim (ORCID: https://orcid.org/0000-0002-0346-2871)
- Paul Gustafson
- Shaun R. Seaman (ORCID: https://orcid.org/0000-0003-3726-5937)
- Julie Bruneau (ORCID: https://orcid.org/0000-0002-3484-6456)
- Bohdan Nosyk (ORCID: https://orcid.org/0000-0003-2513-3718)
- Kevin Schnepel (ORCID: https://orcid.org/0000-0002-7854-0790)
- Robert W. Platt (ORCID: https://orcid.org/0000-0002-5981-8443)
- Lawrence C. McCandless (ORCID: https://orcid.org/0000-0002-8752-2105)
- Megan Kurz
- Fahmida Homayra
- Ruyu Yan
- Sander Greenland
- Thomas M. Loughin
Institutions
- Portland State University (US)
- Harvard University (US)
- University of British Columbia (CA)
- Oregon Health & Science University (US)
- Simon Fraser University (CA)
- University of Cambridge (GB)
- Massachusetts General Hospital (US)
- British Columbia Centre on Substance Use (CA)
- UMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik (AT)
- MRC Biostatistics Unit (GB)
- Centre for Advancing Health Outcomes (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- McGill University (CA)
- Université de Montréal (CA)
- University of Pennsylvania (US)
- Medical Research Council (GB)
Publication Details
- Journal
- JAMA
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1001/jama.2024.16954
- Citations
- 44
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 23.89