Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer
In cohort study of patients with metastatic PDA, BMI was not associated with survival. Higher visceral fat density, subcutaneous fat area, and muscle-to-fascia ratio were associated with survival independent of BMI. The latter 2 were associated with higher levels of animal product metabolism. These findings could represent novel focuses for prognostication and intervention to improve survival of patients with PDA.
Authors
- Valerie Gunchick (ORCID: https://orcid.org/0000-0002-9392-0644)
- Grace L. Su (ORCID: https://orcid.org/0000-0002-8701-774X)
- Stewart C. Wang (ORCID: https://orcid.org/0000-0001-7780-7687)
- Edward B. Brown (ORCID: https://orcid.org/0000-0002-5367-5330)
- Jason W. Locasale (ORCID: https://orcid.org/0000-0002-7766-3502)
- Vaibhav Sahai (ORCID: https://orcid.org/0000-0003-1892-1548)
- P. A. Philip
- Juan Liu (ORCID: https://orcid.org/0000-0002-4440-9065)
Institutions
- Duke University (US)
- Morpho (United States) (US)
- Wayne State University (US)
- University of Michigan (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- VA Ann Arbor Healthcare System (US)
- Analysis Group (United States) (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.40047
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.85