The <scp>IL</scp>‐4–<scp>IL</scp>‐<scp>4Rα</scp> axis modulates olfactory neuroimmune signaling to induce loss of smell
IL-4 and IL-13 have non-redundant effects in olfaction, with loss of smell in mice evoked only by intranasal administration of IL-4, but not IL-13. IL-4-evoked pathophysiological effects on olfaction is independent of compromised structural integrity of the olfactory neuroepithelium. IL-4-IL-4Rα signaling modulates neuronal crosstalk with immune cells, suggesting a functional link between olfactory impairment and neuroinflammation. Abbreviations: IL, interleukin; KO, knock-out; wk, week; WT, wild-type.
Authors
- Peter Piepenhagen
- Giorgio Gaglia (ORCID: https://orcid.org/0000-0002-5179-4256)
- Hamid Mattoo (ORCID: https://orcid.org/0000-0002-5415-9661)
- Mithilesh Kumar Jha (ORCID: https://orcid.org/0000-0002-9526-0053)
- Yannis Hara (ORCID: https://orcid.org/0000-0002-2084-971X)
- Seblewongel Asrat (ORCID: https://orcid.org/0000-0001-9953-7120)
- Jamie Marie Orengo (ORCID: https://orcid.org/0000-0002-2695-6508)
- Juby A. Jacob‐Nara (ORCID: https://orcid.org/0000-0002-5372-8762)
- Scott Nash (ORCID: https://orcid.org/0000-0001-9208-5280)
- Dinesh S. Bangari (ORCID: https://orcid.org/0000-0002-9909-1146)
- Jeremy Huang (ORCID: https://orcid.org/0000-0002-6847-3109)
- Emanuele de Rinaldis (ORCID: https://orcid.org/0000-0002-0221-1114)
- Alexandra Hicks (ORCID: https://orcid.org/0009-0009-6910-6990)
- Yingnan Han (ORCID: https://orcid.org/0000-0002-6356-4052)
- Ingeborg Maria Langohr (ORCID: https://orcid.org/0000-0001-7366-4391)
- Kaitlyn Gayvert (ORCID: https://orcid.org/0000-0001-9135-6501)
- Wei Keat Lim (ORCID: https://orcid.org/0000-0002-6226-2570)
- Cheng Zhu (ORCID: https://orcid.org/0000-0003-3632-6435)
Institutions
- Regeneron (United States) (US)
- AVEO Oncology (United States) (US)
- Sanofi (United States) (US)
Publication Details
- Journal
- Allergy
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1111/all.16338
- Citations
- 10
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.61
Funders
- Sanofi
- Regeneron Pharmaceuticals