Chemical inactivation of two non-enveloped viruses results in distinct thermal unfolding patterns and morphological alterations
The distinct effects of the chemical treatment on the morphology of HAdV5 and FCV suggests that non-enveloped viruses with icosahedral geometry can follow different morphological pathways to inactivation. Synergistic effect of whole formulation is more effective compared to individual components. Molecular level understanding of inactivation pathways may result in the design and development of effective mass-market formulations for rapid neutralization of non-enveloped viruses.
Authors
- Sayandip Mukherjee (ORCID: https://orcid.org/0000-0002-1669-4874)
- Manidipa Banerjee (ORCID: https://orcid.org/0000-0001-6202-5965)
- Milan Kumar Lokshman
- Sandip B. Pathak
- Pankhuri Narula
Institutions
- Unilever (India) (IN)
- Indian Institute of Technology Delhi (IN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1186/s12866-024-03565-1
- Citations
- 9
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- Unilever
- Department of Biotechnology, Ministry of Science and Technology, India
- Indian Institute of Technology Delhi