Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice
cSiO<sub>2</sub> evoked robust pulmonary inflammation and fibrosis in NZBWF1 mice that was evident at 7 days PI and progressed to ELS development and autoimmunity by 28 days PI. sEH inhibition by TPPU modestly suppressed cSiO<sub>2</sub>-induced cellularity changes and pulmonary fibrosis. However, TPPU did not affect ELS formation or autoantibody responses, suggesting sEH minimally impacts cSiO<sub>2</sub>-triggered lung inflammation, fibrosis, and early autoimmunity in our model.
Authors
- Vicente Estrada (ORCID: https://orcid.org/0000-0002-7795-5986)
- Elham Pourmand
- Jack R. Harkema (ORCID: https://orcid.org/0000-0003-4682-0824)
- James J. Pestka (ORCID: https://orcid.org/0000-0003-4689-2756)
- Kin Sing Stephen Lee (ORCID: https://orcid.org/0000-0003-4541-3063)
- James G. Wagner (ORCID: https://orcid.org/0000-0002-4216-0753)
- Megha Singhal
- Lauren K. Heine
- Ryan P. Lewandowski
- Olivia F. McDonald (ORCID: https://orcid.org/0000-0001-9164-7077)
Institutions
- Los Alamos National Laboratory (US)
- Michigan State University (US)
Publication Details
- Journal
- Inhalation Toxicology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1080/08958378.2024.2413373
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- National Science Foundation
- Lupus Foundation of America
- Michigan State University
- National Institutes of Health
- College of Engineering, Michigan State University