Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase
CR enhances insulin sensitivity by promoting PTGIS expression and stimulating the TUG cleavage pathway, leading to increased GLUT4 translocation to the cell surface and decreased GLUT4 carbonylation. These findings shed light on the complex molecular mechanisms through which CR favorably impacts insulin sensitivity and metabolic health.
Authors
- Salim Merali (ORCID: https://orcid.org/0000-0002-0280-5289)
- Carl F. Pieper (ORCID: https://orcid.org/0000-0003-4809-1725)
- Carmen Merali (ORCID: https://orcid.org/0000-0003-4679-710X)
- Carlos A. Barrero (ORCID: https://orcid.org/0000-0001-5779-6642)
- Connor Quinn (ORCID: https://orcid.org/0009-0005-6916-5641)
- Kim M. Huffman (ORCID: https://orcid.org/0000-0003-4708-4734)
- Jonathan S. Bogan (ORCID: https://orcid.org/0000-0001-6463-8466)
Institutions
- Duke University (US)
- Yale University (US)
- Clinical Research Institute (US)
- Temple University (US)
Publication Details
- Journal
- Obesity
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1002/oby.24150
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- National Institutes of Health