Discordance of human epidermal growth factor receptor 2‐low status between breast primary and distant metastases with clinical–pathological correlation
A significant proportion of previous 'HER2-negative' primaries and DM cases were reclassified as HER2-low. Discordant HER2 status between IBC primary and metastasis and between different DM sites demonstrated tumour heterogeneity and highlights the need for HER2 retesting in distant metastasis.
Authors
- Timothy M. D’Alfonso
- Hannah Yong Wen (ORCID: https://orcid.org/0000-0001-6794-5234)
- Monica Morrow (ORCID: https://orcid.org/0000-0003-4636-8313)
- Edi Brogi (ORCID: https://orcid.org/0000-0003-4737-8468)
- Ellen Yang (ORCID: https://orcid.org/0009-0008-9557-5988)
Institutions
- Mount Sinai Hospital (CA)
- Northwell Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- North Shore University Hospital (US)
Publication Details
- Journal
- Histopathology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1111/his.15346
- Citations
- 5
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 1.41